Myeloperoxidase MPO is the most toxic enzyme found in the azurophilic granules of neutrophils MPO utilizes H 2 O 2 to generate hypochlorous acid HClO and other reactive moieties which kill pathogens during infections Myeloperoxidase A new player in autoimmunity Cell Immunol 2017 Jul31718 doi 101016jcellimm201705002 Epub
Myeloperoxidase A new player in autoimmunity PubMed
In the Special Issue entitled Role for the Enzyme Myeloperoxidase to Elicit Pathologies of the International Journal of Molecular Sciences includes a total of seven contributions five original articles and two reviews have collectively provided new information about the role for MPO in health and disease For example Prasch J et al
Europe PMC is an archive of life sciences journal literature
Myeloperoxidase A new player in autoimmunity PMC
NETosis has been linked to a wide array of autoimmune diseases Systemic Lupus Erythematosous SLE Antineutrophil cytoplasmic antibody ANCAassociated vasculitis AAV rheumatoid arthritis cystic fibrosis and gout and in recent years NETs have taken center stage in autoimmunity research as potential links in breaking immune tolerance to
Myeloperoxidase A new player in autoimmunity ScienceDirect
NeutrophilDerived Myeloperoxidase Facilitates Both the Induction and
Myeloperoxidase A New Player In Autoimmunity Pmc
The Dual Role of Myeloperoxidase in Immune Response PMC
Myeloperoxidase MPO is the most toxic enzyme found in the azurophilic granules of neutrophils MPO utilizes H 2 O 2 to generate hypochlorous acid HClO and other reactive moieties which kill pathogens during infections In contrast in the setting of sterile inflammation MPO and MPOderived oxidants are thought to be pathogenic promoting inflammation and causing tissue damage
Therapeutic Myeloperoxidase Inhibition Attenuates Neutrophil Activation
Myeloperoxidase A new player in autoimmunity ScienceDirect
Myeloperoxidase A new player in autoimmunity Europe PMC
Inhibition of Myeloperoxidase at the Peak of Experimental Autoimmune Encephalomyelitis Restores BloodBrainBarrier Integrity and Ameliorates Disease Severity J Neurochem 2016 136 82636 101111jnc13426 PMC free article PubMed CrossRef Google Scholar
Myeloperoxidase A New Player In Autoimmunity Pmc
Keywords Autoimmunity Myeloperoxidase Oxidative stress Multiple sclerosis Rheumatoid arthritis Neutrophil 1 Introduction MPO is a myeloidlineage restricted enzyme with strong antibacterial properties During myeloid cell differentiation MPO is largely expressed by neutrophils where is located within azurophilic granules
NeutrophilDerived Myeloperoxidase Facilitates Both the Induction and
Myeloperoxidase MPO is the most toxic enzyme found in the azurophilic granules of neutrophils MPO utilizes H 2 O 2 to generate hypochlorous acid HClO and other reactive moieties which kill pathogens during infections In contrast in the setting of sterile inflammation MPO and MPOderived oxidants are thought to be pathogenic promoting inflammation and causing tissue damage
23 Reaction Cycles of Myeloperoxidase Halogenation cycle An overview of the major reaction cycles of MPO is given in Figure 1Compound I of MPO which is formed as a result of a reaction between resting MPO and H 2 O 2 is a shortlived very reactive state It interacts rapidly by abstracting two electrons with pseudohalides and oxidizes them to hypohalous acids or hypothiocyanite
Myeloperoxidase in Health and Disease PMC National Center for
Strzepa A Pritchard KA Dittel BN Myeloperoxidase A new player in autoimmunity Cell Immunol 2017 31718 101016jcellimm201705002 PMC free article Google Scholar 16 Pattison DI Davies MJ Reactions of myeloperoxidasederived oxidants with biological substrates gaining chemical insight into human inflammatory diseases